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In particular, Arginine 130 is here shown to be essential for catalysis in analogy with other MAPEGs

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Astrocytic autophagy plasticity Among the diverse dimensions of astrocyte state transitions, autophagy represents a key regulatory axis that allows astrocytes to adapt to metabolic and proteotoxic stress

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Next, we will summarize some promising medicine monomers that activate the GSH system based on the categories of natural medicines, including flavonoids, terpenoids, phenolic acids, quinones, and alkaloids (Table 2, Supplementary Table S2)